Blake Lively was cast in the CW's series Gossip Girl which premiered in September 2007. Lively plays Serena van der Woodsen in the teen drama.While rumors of infighting among the Gossip Girl co-stars have circulated in the tabloids, Blake denies that there is any unfriendly competition on-set. “The media is always trying to pit us against each other," she said in an interview, "I guess because it’s just not interesting to say, ‘Everyone gets along; everybody just works 18-hour days and goes home to sleep.’ That’s not fun to read, I guess.”
Lively' 1st magazine cover was the November 2007 issue of Cosmo Girl, where Lively discussed her time in high school and her career prior to Gossip Girl. She has since appeared on the January 2008 cover of shopping magazine Lucky.
Blake Lively has more recently appeared on the March 2008 cover of Teen Vogue, as well as the May 2008 cover of NYLON with her Gossip Girl co-star Leighton Meester. She appeared on the cover of "Seventeen"'s August 2008 issue. Blake also was on the cover of "Girls' Life"'s August 2008 issue, along with The Sisterhood of the Traveling Pants costars Amber Tamblyn, Alexis Bledel, and America Ferrera. More recently Lively also appeared on the cover of "Cosmopolitan"'s September 2008 issue. Lively has a brief cameo in a pre-recorded Saturday Night Live skit entitled "Murray Hill" alongside James Franco, where she portrays a trans_xual partygoer.